Effect of the proteasome inhibitor MLN519 on the expression of inflammatory molecules following middle cerebral artery occlusion and reperfusion in the rat

@article{Berti2003EffectOT,
  title={Effect of the proteasome inhibitor MLN519 on the expression of inflammatory molecules following middle cerebral artery occlusion and reperfusion in the rat},
  author={Rossana Berti and Antony J. Williams and Luisa C Velarde and John R. Moffett and Peter J. Elliott and Julian Adams and Changping Yao and Jitendra R. Dave and Frank C. Tortella},
  journal={Neurotoxicity Research},
  year={2003},
  volume={5},
  pages={505-514}
}
Anti-inflammatory treatment with the proteasome inhibitor MLN519 has been previously reported to be neuroprotective against ischemic brain injury in rats. These effects have been related to inhibition of the transcription factor NF-κB, which is activated through ubiquitin-proteasomal degradation. The aim of this study was to evaluate the effects of MLN519… CONTINUE READING