• DOI:10.1113/expphysiol.1997.sp004017
Corpus ID: 25094186

Effect of the potassium channel opener ZM260384 on skeletal muscle function during restricted blood flow in the anaesthetized cat

@article{Wickenden1997EffectOT,
  title={Effect of the potassium channel opener ZM260384 on skeletal muscle function during restricted blood flow in the anaesthetized cat},
  author={A. Wickenden and R. Brooks and E. Kelly and K. Russell and P. Kumar and S. Poucher},
  journal={Experimental Physiology},
  year={1997},
  volume={82}
}

A. Wickenden, R. Brooks, +3 authors S. Poucher

Published 1997

Chemistry, Medicine

Experimental Physiology

The aim of the present experiment was to determine whether the potassium channel opener 2‐(2,2‐bis(difluoromethyl)‐6‐nitro‐3,4‐dihydro‐2H‐1, 4‐benzoxazine‐4‐yl)pyridine‐N‐oxide (ZM260384) was capable of accelerating the decline in skeletal muscle function during restricted blood flow in vivo. Cats (3.0‐4.5 kg body weight) were anaesthetized with alphaxalone‐alphadalone and breathed spontaneously following tracheotomy. Isometric tension was measured in the extensor digitorum longus‐anterior… CONTINUE READING

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