Effect of the phorbol ester TPA on PTH secretion. Evidence for a role for protein kinase C in the control of PTH release.

@article{Brown1984EffectOT,
  title={Effect of the phorbol ester TPA on PTH secretion. Evidence for a role for protein kinase C in the control of PTH release.},
  author={Edward Meigs Brown and Jamie Redgrave and J. G. Thatcher},
  journal={FEBS letters},
  year={1984},
  volume={175 1},
  pages={
          72-5
        }
}
Parathyroid hormone (PTH) secretion is stimulated by low extracellular calcium (Ca2+) in association with a reduction in cyosolic Ca2+, indicating that this cell type does not conform to classical models of stimulus-secretion coupling. We used the phorbol ester TPA (12-O-tetradecanoyl phorbol 13-acetate), which directly activates protein kinase C, to investigate the possible role of this enzyme in the unusual secretory properties of the parathyroid cell. TPA causes a dose-dependent stimulation… CONTINUE READING
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