Effect of the novel anxiolytic drug deramciclane on cytochrome P450 2D6 activity as measured by desipramine pharmacokinetics

@article{Laine2003EffectOT,
  title={Effect of the novel anxiolytic drug deramciclane on cytochrome P450 2D6 activity as measured by desipramine pharmacokinetics},
  author={K. Laine and S. D. Bruyn and Harry Bj{\"o}rklund and J. Rouru and J. H{\"a}nninen and H. Scheinin and M. Anttila},
  journal={European Journal of Clinical Pharmacology},
  year={2003},
  volume={59},
  pages={893-898}
}
BackgroundIn vitro findings have indicated that the novel anxiolytic drug, deramciclane, is an inhibitor of the cytochrome P450 (CYP) 2D6 enzyme and co-administration of deramciclane and the CYP2D6 probe drug desipramine is possible in clinical practice.ObjectiveTo evaluate the effects of deramciclane on CYP2D6 activity as measured by desipramine pharmacokinetics and pharmacodynamics using paroxetine as a positive control for CYP2D6 inhibition.MethodsFifteen healthy subjects received either 60… Expand
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The effect of mirabegron, a potent and selective β3-adrenoceptor agonist, on the pharmacokinetics of CYP2D6 substrates desipramine and metoprolol
ROLE OF CYP2E1 IN DERAMCICLANE METABOLISM
MECHANISM-BASED INACTIVATION OF CYP 2 D 6 BY METHYLENEDIOXYMETHAMPHETAMINE
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MECHANISM-BASED INACTIVATION OF CYP2D6 BY METHYLENEDIOXYMETHAMPHETAMINE
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