Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone

@article{Laine2003EffectOT,
  title={Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone},
  author={K. Laine and O. Ahokoski and R. Huupponen and J. H{\"a}nninen and S. Palovaara and J. Ruuskanen and Harry Bj{\"o}rklund and M. Anttila and J. Rouru},
  journal={European Journal of Clinical Pharmacology},
  year={2003},
  volume={59},
  pages={761-766}
}
RationalePreliminary in vitro findings indicated that the novel anxiolytic drug, deramciclane is a substrate for the cytochrome P450 (CYP) 3A4 isoenzyme. Moreover, its co-administration with buspirone, another anxiolytic drug, is likely in clinical practice.ObjectivesThe primary objective of the present study was to evaluate the in vivo effects of deramciclane on CYP3A4 activity as measured by buspirone pharmacokinetics. The secondary objective was to study the possible pharmacodynamic… Expand
Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes
Extending therapeutic use of psychostimulants: Focus on serotonin-1A receptor
  • D. Haleem
  • Medicine, Psychology
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2013
CYTOCHROME P450 3A-MEDIATED METABOLISM OF BUSPIRONE IN HUMAN LIVER MICROSOMES
...
1
2
...

References

SHOWING 1-10 OF 26 REFERENCES
The effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of buspirone
Pharmacokinetics and safety of deramciclane during multiple oral dosing.
The single dose pharmacokinetics and safety of deramciclane in healthy male volunteers
Metabolism of the antianxiety drug buspirone in human subjects.
Metabolism and disposition of buspirone.
Quantifying the 5-HT1A agonist action of buspirone in man
Comparative effects of a repeated dose regime of diazepam and buspirone on subjective ratings, psychological tests and the EEG
Deramciclane in the treatment of generalized anxiety disorder: A placebo-controlled, double-blind, dose-finding study
...
1
2
3
...