Effect of the nature of the spacer on gene transfer efficacies of novel thiocholesterol derived gemini lipids in different cell lines: a structure-activity investigation.

@article{Bajaj2008EffectOT,
  title={Effect of the nature of the spacer on gene transfer efficacies of novel thiocholesterol derived gemini lipids in different cell lines: a structure-activity investigation.},
  author={Avinash Bajaj and Paturu Kondaiah and Santanu Bhattacharya},
  journal={Journal of medicinal chemistry},
  year={2008},
  volume={51 8},
  pages={2533-40}
}
A structure-activity investigation was undertaken to see the effect of the nature of the spacer on the gene transfection efficacies of thiocholesterol-derived cationic gemini lipids possessing disulfide linkage between the cationic headgroup and the thiocholesterol moiety. Three gemini cationic lipids possessing hydrophobic flexible (-(CH 2) 5-; 1), hydrophobic rigid (-C 6H 4-; 2), and hydrophilic flexible (-CH 2-CH 2-O-CH 2-CH 2-; 3) spacer segments were synthesized. In HeLa cells, lipid… CONTINUE READING

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