Effect of the multifunctional cosmetic ingredient sphinganine on hair loss in males and females with diffuse hair reduction

@inproceedings{Gerlach2016EffectOT,
  title={Effect of the multifunctional cosmetic ingredient sphinganine on hair loss in males and females with diffuse hair reduction},
  author={Nicole Gerlach and Matthias Mentel and Tim K{\"o}hler and Benjamin Tuchscherer and Birgit Garbe and Jasmina {\"U}lker and Hagen Prof. Dr. Tronnier and Ulrike I Heinrich and Mike Farwick},
  booktitle={Clinical, cosmetic and investigational dermatology},
  year={2016}
}
Sphingolipids are well known to promote keratinocyte differentiation and to induce ceramide production. In addition, they show anti-inflammatory and antimicrobial activities. Thus, the aim of this study is to investigate the potential effect of sphinganine on prolonging the hair anagen rate and improving the overall hair quality and scalp health. The inhibitory potential of sphinganine toward 5-α-reductase was studied using an in vitro assay. The stimulation of the antimicrobial peptide HBD2 by… CONTINUE READING
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