Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells

@article{Kamau2005EffectOT,
  title={Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells},
  author={Sarah W. Kamau and Stefanie D. Kr{\"a}mer and Maja Guenthert and Heidi Wunderli-Allenspach},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2005},
  volume={41},
  pages={207-216}
}
Multidrug resistance (MDR) is a major obstacle in cancer therapy. It results from different mechanisms; among them is P-glycoprotein (P-gp)-mediated drug efflux out of cells. The mechanism of action remains elusive. The membrane lipid surrounding of P-gp, especially cholesterol, has been postulated to play an important role. To determine the effect of cholesterol depletion on P-gp, Madin Darby canine kidney (MDCK) cells, transfected with the mdr1 gene (MDR1-MDCK cells), were treated with methyl… CONTINUE READING