Effect of the microtubule disrupting agents, colchicine and vinblastine, on seminiferous tubule structure in the rat.

@article{Russell1981EffectOT,
  title={Effect of the microtubule disrupting agents, colchicine and vinblastine, on seminiferous tubule structure in the rat.},
  author={Lonnie D. Russell and James P. Malone and D S MacCurdy},
  journal={Tissue & cell},
  year={1981},
  volume={13 2},
  pages={349-67}
}
Injections of colchicine or vinblastine were given intratesticularly and rats sacrificed 6 and 12 hr later. Colchicine and vinblastine produced identical morphological patterns of response in the seminiferous tubules resulting in arrest of germcell mitoses and meioses and a rapid depletion of the microtubules normally found within the Sertoli cell. Sloughing of cells into the lumen of seminiferous tubules was the most prominent feature noted. Germ cells and portions of the apical Sertoli cells… CONTINUE READING