Effect of the kappa-opioid receptor agonist, U69593, on reinstatement of extinguished amphetamine self-administration behavior

@article{Schenk2001EffectOT,
  title={Effect of the kappa-opioid receptor agonist, U69593, on reinstatement of extinguished amphetamine self-administration behavior},
  author={Susan Schenk and Brian Partridge},
  journal={Pharmacology Biochemistry and Behavior},
  year={2001},
  volume={68},
  pages={629-634}
}
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TLDR
The failure of U69593 to attenuate GBR 12909- or WIN 35,428-produced cocaine seeking suggests that the effect of this kappa-opioid receptor agonist on cocaine seeking is not mediated by interactions at the dopamine transporter.
U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking
TLDR
U69593 attenuates cocaine self-administration and the reinstatement of drug-taking behavior which occurs in response to experimenter-administered cocaine.
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TLDR
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TLDR
Findings indicate that manipulations known to block the induction of locomotor and dopaminergic sensitization by amphetamine also block the facilitation of drug self-administration, and suggest an important and common role for D1 DA receptor activation in the development of enhanced responding to and for drug.
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