Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection.

@article{Nakanishi2010EffectOT,
  title={Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection.},
  author={Tomonori Nakanishi and Tatsuaki Morokata and Kaori Kubo and Hitomi Umeno and Yoshiteru Eikyu and Yoshihiro Kozuki and Nobuo Seki},
  journal={International immunopharmacology},
  year={2010},
  volume={10 1},
  pages={
          91-7
        }
}
Inosine 5'-monophosphate dehydrogenase (IMPDH) inhibition is a critical target in solid organ transplantation, and the development of mycophenolate mofetil (MMF) represents a major advance in transplant medicine. In this study, the in vitro and in vivo pharmacological effects of BMS-566419, a novel chemically synthesized IMPDH inhibitor, were compared to those of mycophenolic acid (MPA) and MMF based on results from several immunological experiments. The in vitro inhibitory activity of BMS… Expand
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