Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes.

Abstract

Trichostatin A (TSA) is a histone deacetylase inhibitor that has antiproliferative and differentiation-inducing effects on cancer cells, and in cultures of primary hepatocytes has been shown to maintain xenobiotic metabolic capacity. Using an NMR-based metabolic profiling approach, we evaluated if the endogenous metabolome was stabilized and the normal… (More)
DOI: 10.1021/pr9007656

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