Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs.

@article{Akao2006EffectOT,
  title={Effect of the free radical scavenger MCI-186 on pulmonary ischemia-reperfusion injury in dogs.},
  author={Takahiko Akao and Izumi Takeyoshi and Osamu Totsuka and Kazuhisa Arakawa and Masato Muraoka and Katsumi Kobayashi and Kenjiro Konno and Koshi Matsumoto and Yasuo Morishita},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2006},
  volume={25 8},
  pages={965-71}
}
BACKGROUND Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage, and it was suggested that oxygen free radicals contribute to ischemia-reperfusion injury induced by cerebral ischemic damage. MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent scavenger and inhibitor of hydroxyl radicals and protective agent of peroxidative injury. The purpose of this study was to evaluate the effects of MCI-186 on pulmonary ischemia-reperfusion… CONTINUE READING

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Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage , and it was suggested that oxygen free radicals contribute to ischemia - reperfusion injury induced by cerebral ischemic damage .
Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage , and it was suggested that oxygen free radicals contribute to ischemia - reperfusion injury induced by cerebral ischemic damage .
Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage , and it was suggested that oxygen free radicals contribute to ischemia - reperfusion injury induced by cerebral ischemic damage .
Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage , and it was suggested that oxygen free radicals contribute to ischemia - reperfusion injury induced by cerebral ischemic damage .
Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage , and it was suggested that oxygen free radicals contribute to ischemia - reperfusion injury induced by cerebral ischemic damage .
MCI-186 ( 3-methyl-1-phenyl-2-pyrazolin-5-one ) is a potent scavenger and inhibitor of hydroxyl radicals and protective agent of peroxidative injury .
Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage , and it was suggested that oxygen free radicals contribute to ischemia - reperfusion injury induced by cerebral ischemic damage .
Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage , and it was suggested that oxygen free radicals contribute to ischemia - reperfusion injury induced by cerebral ischemic damage .
Free radical scavengers and superoxide dismutase have been found to protect against cerebral ischemic damage , and it was suggested that oxygen free radicals contribute to ischemia - reperfusion injury induced by cerebral ischemic damage .
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