Effect of the fluoropyrimidines 5-fluorouracil and doxifluridine on cellular uptake of thiamin.

Abstract

The effect of 5-fluorouracil (5-FU) and doxifluridine on cellular uptake and phosphorylation of thiamin was studied in two different cell systems. Uptake of 14C-Thiamine in human NHIK 3025 cells preincubated for 24 h with 0.05 mM 5-FU or 0.1 mM doxifluridine was increased by 22-26% relative to nontreated control cells. In isolated rat hepatocytes a drug… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.