Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis. Comparison with conventional therapy.

@article{Riggs1982EffectOT,
  title={Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis. Comparison with conventional therapy.},
  author={B. Lawrence Riggs and E. R. BernsteinJeffrey I. Seeman and Stephen Hodgson and Donald R. Taves and W Michael O'fallon},
  journal={The New England journal of medicine},
  year={1982},
  volume={306 8},
  pages={446-50}
}
We assessed the rates of vertebral fracture in patients with postmenopausal osteoporosis. Forty-five patients were not treated (91 person-years of observation); 59 were treated conventionally, with calcium (alone or combined with estrogen) or vitamin D or both (218 years); and 61 were treated with sodium fluoride combined with conventional therapy (251 years). The fracture rate (per thousand person-years) was 834 in untreated patients, 419 in those given calcium with or without vitamin D, 304… CONTINUE READING