Effect of the endogenous κ opioid agonist dynorphin A(1–17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice

@article{Zhang2003EffectOT,
  title={Effect of the endogenous κ opioid agonist dynorphin A(1–17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice},
  author={Yong Zhang and Eduardo Roque Butelman and Stefan D. Schlussman and Ann Ho and Mary Jeanne Kreek},
  journal={Psychopharmacology},
  year={2003},
  volume={172},
  pages={422-429}
}
RationaleEffects of synthetic kappa opioid receptor agonists on cocaine-induced reward have been studied extensively in rats but relatively few studies have used the endogenous kappa agonist dynorphin A(1–17).ObjectivesThree studies were conducted to examine the effect of the natural sequence dynorphin on cocaine-induced increases in dopamine, on the formation of conditioned place preference and on increases in locomotor activity in C57BL/6 J mice.MethodsAfter implantation of guide cannulae… CONTINUE READING

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Opioids, dopamine, stress, and the addictions

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