Effect of the dosing interval on myelotoxicity and survival in mice treated by cytarabine.

Abstract

Many antineoplastic drugs are cell-cycle-phase-specific. These drugs are often highly toxic to the host, as they have the potential to impair replication, not only in the cancer cells, but also in the normal tissues. Using mathematical models it has been shown how selectivity of these drugs can be increased by exploiting the relatively large variability in… (More)

Topics

Cite this paper

@article{Agur1992EffectOT, title={Effect of the dosing interval on myelotoxicity and survival in mice treated by cytarabine.}, author={Z. Agur and Rainer M. W. Arnon and Belmont Schechter}, journal={European journal of cancer}, year={1992}, volume={28A 6-7}, pages={1085-90} }