Effect of the cannabinoid ajulemic acid on rat models of neuropathic and inflammatory pain

  title={Effect of the cannabinoid ajulemic acid on rat models of neuropathic and inflammatory pain},
  author={Vanessa A. Mitchell and Sevda Aslan and Reza Safaei and Christopher W. Vaughan},
  journal={Neuroscience Letters},

Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain

Tramadol and WIN55212 combination produces antinociceptive effects in neuropathic but not inflammatory pain at low doses with no additional risk of locomotor impairment, which may be useful in clinical practice.

Role of Cannabinoids in the Treatment of Pain and (Painful) Spasticity

Patients with unsatisfactory response to other methods of pain therapy and who were characterized by failed stress adaptation particularly benefited from treatment with cannabinoids, but none of the attempts to overcome the disadvantage of the narrow therapeutic index have resulted in a major breakthrough.

The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain

Preclinical and clinical evidence of various endocannabinoid system targets as potential therapeutic strategies for inflammatory and neuropathic pain conditions are examined.

Cannabimimetic Properties of Ajulemic Acid

It is shown that AJA, like Δ9-THC, exhibits psychoactive and therapeutic effects at nearly equal doses in preclinical models, suggesting similar limitations in their putative therapeutic profiles.

Persistent inflammation promotes endocannabinoid release and presynaptic cannabinoid 1 receptor desensitization

Adaptations within the endogenous cannabinoid system during inflammatory pain have important implications for the development of future pain therapies targeting CB1Rs or MAGL.

Ajulemic Acid, a Synthetic Nonpsychoactive Cannabinoid Acid, Bound to the Ligand Binding Domain of the Human Peroxisome Proliferator-activated Receptor γ*

The crystal structure of the ligand binding domain of the γ isotype of human PPAR in complex with ajulemic acid shows a binding mode that is compatible with other known partial agonists of PPAR, explaining their moderate activation of the receptor, and provides clues to the understanding of partial agonism itself.

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

This review covers reports published in the last 5 years on the anti-inflammatory activities of all classes of cannabinoids, including phytocannabinoids such as tetrahydrocannabinol and cannabidiol,

Pharmacological characterisation of place escape/avoidance behaviour in the rat chronic constriction injury model of neuropathic pain

The place escape/avoidance paradigm may enable discrimination between selected drug classes on distinct components of sensory and affective pain processing in rats with neuropathic pain.



Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial.

In this preliminary study, CT-3 was effective in reducing chronic neuropathic pain compared with placebo and no major adverse effects were observed.

The synthetic cannabinoid WIN55,212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain

The data indicate that cannabinoids may have therapeutic potential in neuropathic pain, and that this effect is mediated through the CB1 receptor.

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

  • M. IbrahimH. Deng T. Malan
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
AM1241 dose-dependently reversed tactile and thermal hypersensitivity produced by ligation of the L5 and L6 spinal nerves in rats, demonstrating a mechanism leading to the inhibition of pain, one that targets receptors localized exclusively outside the CNS.

Cannabinoid receptors and pain

  • R. Pertwee
  • Biology, Chemistry
    Progress in Neurobiology
  • 2001