Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells.

@article{Saffi2010EffectOT,
  title={Effect of the anti-neoplastic drug doxorubicin on XPD-mutated DNA repair-deficient human cells.},
  author={Jenifer Saffi and Mateus H. Agnoletto and Temenouga Nikolova Guecheva and Luis Francisco Zirnberger Batista and Helot{\^o}nio Carvalho and Jo{\~a}o Ant{\^o}nio P{\^e}gas Henriques and Anne Stary and Carlos Frederico Martins Menck and Alain Sarasin},
  journal={DNA repair},
  year={2010},
  volume={9 1},
  pages={
          40-7
        }
}
Doxorubicin (DOX), a member of the anthracycline group, is a widely used drug in cancer therapy. The mechanisms of DOX action include topoisomerase II-poisoning, free radical release, DNA adducts and interstrand cross-link (ICL) formation. Nucleotide excision repair (NER) is involved in the removal of helix-distorting lesions and chemical adducts, however, little is known about the response of NER-deficient cell lines to anti-tumoral drugs like DOX. Wild type and XPD-mutated cells, harbouring… CONTINUE READING

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