Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem.

@article{Gao2003EffectOT,
  title={Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem.},
  author={Su Qin Gao and Melissa D. Lane},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 10},
  pages={5628-33}
}
Intraperitoneal (i.p.) injection of C75, a fatty acid synthase inhibitor, causes a rapid (<or=2-h) and persistent (to at least 24-h) approximately 95% decrease in food intake. The persistent effect seems to be due to inhibition of the fasting-induced up-regulation of expression of hypothalamic orexigenic neuropeptides neuropeptide Y and agouti-related protein and down-regulation of expression of anorexigenic neuropeptides pro-opiomelanocortinalpha-melanocyte-stimulating hormone and cocaine… CONTINUE READING

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