Effect of the angiotensinogen genotype on experimental hypertension in mice

@article{Handtrack2007EffectOT,
  title={Effect of the angiotensinogen genotype on experimental hypertension in mice},
  author={Claudia Handtrack and Nada Cordasic and Bernd Klanke and Roland Veelken and Karl Friedrich Hilgers},
  journal={Journal of Molecular Medicine},
  year={2007},
  volume={85},
  pages={343-350}
}
Polymorphisms of the angiotensinogen (Agt) gene may affect blood pressure. We used a mouse model to test for the role of the Agt genotype in low-renin or high-renin forms of hypertension. Mice bearing one, two, three, or four copies of the Agt gene underwent renal artery clipping to induce high-renin two-kidney, one-clip renovascular hypertension (2K1C), or uninephrectomy, salt loading, and application of deoxycorticosterone-acetate (DOCA) pellets to induce low-renin mineralocorticoid… CONTINUE READING

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