Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers.

@article{Chung2005EffectOT,
  title={Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers.},
  author={Jae-Yong Chung and Joo Youn Cho and Kyung-Sang Yu and Jung-Ryul Kim and Hye-Ryung Jung and K J Lim and I. C. Jang and S Shin},
  journal={Clinical pharmacology and therapeutics},
  year={2005},
  volume={77 6},
  pages={486-94}
}
OBJECTIVE Our objective was to investigate the effect of the uridine 5'-diphosphate-glucuronosyltransferase (UGT) 2B15 genetic polymorphism on the pharmacokinetics and pharmacodynamics of lorazepam in basal, inhibited, and induced metabolic states in healthy normal volunteers. METHODS Twenty-four healthy subjects were enrolled and grouped into UGT2B15*1/*1 or UGT2B15*2/*2 genotype groups. The pharmacokinetic and pharmacodynamic profiles of intravenous lorazepam were characterized before and… CONTINUE READING

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