Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase.

  title={Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase.},
  author={William M Nauseef and M C Cogley and Sara J. McCormick},
  journal={The Journal of biological chemistry},
  volume={271 16},
Human neutrophil microbicidal activity is largely mediated by reactive species generated by the oxygen-dependent myeloperoxidase (MPO) system. Peroxidase-negative neutrophils from many patients with hereditary MPO deficiency possess a 90-kDa MPO-related protein. We recently identified a missense mutation, R569W, in the MPO gene of many subjects with MPO deficiency. In these studies we examined the consequences of R569W on MPO biosynthesis and processing, using stably transfected K562 cells… CONTINUE READING

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