Effect of the R(−) and S(+) isomers of MDA and MDMA on phosphotidyl inositol turnover in cultured cells expressing 5-HT2A or 5-HT2C receptors

@article{Nash1994EffectOT,
  title={Effect of the R(−) and S(+) isomers of MDA and MDMA on phosphotidyl inositol turnover in cultured cells expressing 5-HT2A or 5-HT2C receptors},
  author={J. F. Nash and B. Roth and J. Brodkin and D. Nichols and G. Gudelsky},
  journal={Neuroscience Letters},
  year={1994},
  volume={177},
  pages={111-115}
}
  • J. F. Nash, B. Roth, +2 authors G. Gudelsky
  • Published 1994
  • Chemistry, Medicine
  • Neuroscience Letters
  • The effect of the R(-) and S(+) isomers of 3,4-methylenedioxyamphetamine (MDA) and its N-methyl analog 3,4-methylenedioxymethamphetamine (MDMA) on [3H]inositol monophosphate accumulation was studied in cells expressing either 5-HT2A or 5-HT2C receptors. The isomers of MDA produced a concentration dependent increase in phosphatidyl inositol (PI) hydrolysis at the 5-HT2A receptors, with the R(-) isomer of MDA being more potent than the S(+) at the 5-HT2A receptor. The R(-) and S(+) isomers of… CONTINUE READING
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