Effect of the P450 oxidoreductase *28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers

@article{Zhang2012EffectOT,
  title={Effect of the P450 oxidoreductase *28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers},
  author={Jingjing Zhang and Hua Zhang and Xiao-Liang Ding and Sheng Ma and Li-yan Miao},
  journal={European Journal of Clinical Pharmacology},
  year={2012},
  volume={69},
  pages={807-812}
}
To assess the influence of the P450 oxidoreductase *28 SNP (POR*28) on tacrolimus pharmacokinetics in the Chinese population. Seventy-one healthy Chinese volunteers enrolled in the study received an oral dose of 2 mg of tacrolimus after providing written informed consent. CYP3A5*3 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and POR*28 was genotyped by PCR-direct sequencing. Tacrolimus whole blood concentrations were determined by ultra… CONTINUE READING
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