Effect of the NADPH oxidase inhibitor apocynin on septic lung injury in guinea pigs.

@article{Wang1994EffectOT,
  title={Effect of the NADPH oxidase inhibitor apocynin on septic lung injury in guinea pigs.},
  author={Wen Wang and Yasuhiro Suzuki and Takehiko Tanigaki and David R. Rank and Thomas A. Raffin},
  journal={American journal of respiratory and critical care medicine},
  year={1994},
  volume={150 5 Pt 1},
  pages={
          1449-52
        }
}
Reactive oxygen species (ROS) produced by NADPH oxidase activation in neutrophils play a major role in mediating sepsis-induced acute lung injury. To provide insight into whether the NADPH oxidase inhibitor apocynin might attenuate oxidant-induced lung injury, we examined the effect of apocynin on (1) sepsis-induced lung injury in guinea pigs, (2) ROS generation by LPS-stimulated neutrophils measured by chemiluminescence (CL), and (3) LPS-stimulated neutrophil-mediated human umbilical vein… CONTINUE READING

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A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung.

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