Effect of the N‐methyl‐D‐aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus

  title={Effect of the N‐methyl‐D‐aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus},
  author={E C Bunk and H.-G. K{\"o}nig and J. H. M. Prehn and B P Kirby},
  journal={Journal of Neuroscience Research},
The N‐methyl‐D‐aspartate (NMDA) receptor, one of the ionotropic glutamate receptor, plays important physiological and pathological roles in learning and memory, neuronal development, acute and chronic neurological diseases, and neurogenesis. This work examines the contribution of the NR2B NMDA receptor subunit to adult neurogenesis/cell proliferation under physiological conditions and following an excitotoxic insult. We have previously shown in vitro that a discrete NMDA‐induced, excitotoxic… 

Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive flexibility but not pattern separation

Comparing the effect of NVP-AAM077, CP 101-606, and MK-801 in a series of touch screen tasks that can be used to measure spatial cognition and cognitive flexibility demonstrated that non-selective NMDA antagonism will disrupt numerous aspects of cognitive function.

Activation of Transient Receptor Potential Vanilloid 4 Promotes the Proliferation of Stem Cells in the Adult Hippocampal Dentate Gyrus

It is concluded that TRPV4 activation results in the proliferation of stem cells in the adult hippocampal DG, which is likely mediated through ERK1/2 and p38 MAPK signaling to increase the expression of CDKs and cyclins and accelerate the cell cycle ultimately.

Functional interaction between PDGFβ and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension.

Results indicate that GluN2B-type NMDAR activation may confer to PASMCs antiproliferative and antimigratory properties.

p53 upregulated mediator of apoptosis (Puma) deficiency increases survival of adult neural stem cells generated physiologically in the hippocampus, but does not protect stem cells generated in surplus after an excitotoxic lesion

While neurogenesis is up-regulated in puma-deficient animals following NMDA-induced excitotoxicity to the hippocampal CA1 subfield, puma deficiency could not protect this surplus of newly generated cells from apoptotic cell death.

Control of adult neurogenesis by programmed cell death in the mammalian brain

The extent, mechanism, and biological significance of PCD for the control of adult neurogenesis in the mammalian brain is focused on and the role of intrinsic and extrinsic factors in the regulation at the molecular and systems levels is discussed.

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Understanding the structure, function, pharmacology, roles in neurophysiology, and therapeutic implications for all classes of receptors assembled from the subunits encoded by the 18 ionotropic glutamate receptor genes will advance understanding of many aspects of brain function at molecular, cellular, and system levels.



Negative regulation of neurogenesis and spatial memory by NR2B‐containing NMDA receptors

The findings suggest that NR2B‐containing NMDAR subtypes negatively regulate neurogenesis in the adult hippocampus by activating nNOS activity and thereby hinder the formation of spatial memory.

N‐methyl‐d‐aspartate receptor‐mediated increase of neurogenesis in adult rat dentate gyrus following stroke

These findings indicate that stroke leads to increased neurogenesis in the adult rat dentate gyrus through glutamatergic mechanisms acting on NMDA receptors, and this modulatory effect may be mediated through changes in the levels of several growth factors, which occur after stroke, and could influence various regulatory steps of Neurogenesis.

Activin A Is Essential for Neurogenesis Following Neurodegeneration

This work indicates that activin A, perhaps working in conjunction with other transforming growth factor‐β superfamily molecules, is essential for neurogenesis in the adult central nervous system following excitotoxic neurodegeneration and suggests that neurons can regulate regeneration by suppressing the inflammatory response.

N-Methyl- d -aspartate Receptor Blockade Induces Neuronal Apoptosis in Cortical Culture

The present results demonstrate that NMDA antagonists induce neuronal apoptosis in cortical culture, consistent with the findings obtained in immature rats.

NMDA and AMPA/Kainate Glutamate Receptors Modulate Dentate Neurogenesis and CA3 Synapsin-I in Normal and Ischemic Hippocampus

  • R. BernabeuF. Sharp
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2000
It is proposed that decreased dentate glutamate receptor activation—produced by glutamate receptor antagonists in normal animals and by chronic ischemic hippocampal injury—may trigger dentate neurogenesis and synaptogenesis, which may contribute to memory recovery after hippocampusal injury caused by global ischemia.

Ifenprodil Effects on GluN2B-Containing Glutamate Receptors

Ifenprodil decreased NMDA receptor equilibrium open probability by raising an energetic barrier to activation and also by biasing the receptor toward low open probability gating modes, demonstrating intrinsic effects of ifen Prodil onNMDA receptor stationary gating kinetics.

Kainic acid-mediated excitotoxicity as a model for neurodegeneration

KA-induced excitotoxicity can be used as a model for elucidating mechanisms underlying oxidative stress and inflammation in neurodegenerative diseases and possible intervention by anti-oxidants are suggested.