Effect of the N‐methyl‐D‐aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus

@article{Bunk2014EffectOT,
  title={Effect of the N‐methyl‐D‐aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus},
  author={E C Bunk and H.-G. K{\"o}nig and J. H. M. Prehn and B P Kirby},
  journal={Journal of Neuroscience Research},
  year={2014},
  volume={92}
}
The N‐methyl‐D‐aspartate (NMDA) receptor, one of the ionotropic glutamate receptor, plays important physiological and pathological roles in learning and memory, neuronal development, acute and chronic neurological diseases, and neurogenesis. This work examines the contribution of the NR2B NMDA receptor subunit to adult neurogenesis/cell proliferation under physiological conditions and following an excitotoxic insult. We have previously shown in vitro that a discrete NMDA‐induced, excitotoxic… 

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References

SHOWING 1-10 OF 77 REFERENCES

Negative regulation of neurogenesis and spatial memory by NR2B‐containing NMDA receptors

TLDR
The findings suggest that NR2B‐containing NMDAR subtypes negatively regulate neurogenesis in the adult hippocampus by activating nNOS activity and thereby hinder the formation of spatial memory.

N‐methyl‐d‐aspartate receptor‐mediated increase of neurogenesis in adult rat dentate gyrus following stroke

TLDR
These findings indicate that stroke leads to increased neurogenesis in the adult rat dentate gyrus through glutamatergic mechanisms acting on NMDA receptors, and this modulatory effect may be mediated through changes in the levels of several growth factors, which occur after stroke, and could influence various regulatory steps of Neurogenesis.

Activin A Is Essential for Neurogenesis Following Neurodegeneration

TLDR
This work indicates that activin A, perhaps working in conjunction with other transforming growth factor‐β superfamily molecules, is essential for neurogenesis in the adult central nervous system following excitotoxic neurodegeneration and suggests that neurons can regulate regeneration by suppressing the inflammatory response.

N-Methyl- d -aspartate Receptor Blockade Induces Neuronal Apoptosis in Cortical Culture

TLDR
The present results demonstrate that NMDA antagonists induce neuronal apoptosis in cortical culture, consistent with the findings obtained in immature rats.

NMDA and AMPA/Kainate Glutamate Receptors Modulate Dentate Neurogenesis and CA3 Synapsin-I in Normal and Ischemic Hippocampus

  • R. BernabeuF. Sharp
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2000
TLDR
It is proposed that decreased dentate glutamate receptor activation—produced by glutamate receptor antagonists in normal animals and by chronic ischemic hippocampal injury—may trigger dentate neurogenesis and synaptogenesis, which may contribute to memory recovery after hippocampusal injury caused by global ischemia.

Ifenprodil Effects on GluN2B-Containing Glutamate Receptors

TLDR
Ifenprodil decreased NMDA receptor equilibrium open probability by raising an energetic barrier to activation and also by biasing the receptor toward low open probability gating modes, demonstrating intrinsic effects of ifen Prodil onNMDA receptor stationary gating kinetics.

Kainic acid-mediated excitotoxicity as a model for neurodegeneration

TLDR
KA-induced excitotoxicity can be used as a model for elucidating mechanisms underlying oxidative stress and inflammation in neurodegenerative diseases and possible intervention by anti-oxidants are suggested.
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