Effect of the H1-histamine-like agonist material extracted from bovine spleen on 3': 5'-cyclic nucleotides content in guinea-pig ileal smooth muscle.

The effect of a water-soluble "histamine-free" splenic material that mimics the H1-receptor mediated contractile action of histamine on the guinea-pig ileum has been studied upon concentrations of cGMP and cAMP in slices of this smooth muscle preparation. The splenic extract induced a rapid and sustained decrease in the concentration of cGMP accompanied by… CONTINUE READING