Effect of the CALHM1 G330D and R154H Human Variants on the Control of Cytosolic Ca2+ and Aβ Levels

@inproceedings{Vingtdeux2014EffectOT,
  title={Effect of the CALHM1 G330D and R154H Human Variants on the Control of Cytosolic Ca2+ and Aβ Levels},
  author={Val{\'e}rie Vingtdeux and Jessica E. Tanis and P. S. Chandakkar and Haitian Zhao and Ute Dreses-Werringloer and Fabien Campagne and J. Kevin Foskett and Philippe Marambaud},
  booktitle={PloS one},
  year={2014}
}
CALHM1 is a plasma membrane voltage-gated Ca2+-permeable ion channel that controls amyloid-β (Aβ) metabolism and is potentially involved in the onset of Alzheimer's disease (AD). Recently, Rubio-Moscardo et al. (PLoS One (2013) 8: e74203) reported the identification of two CALHM1 variants, G330D and R154H, in early-onset AD (EOAD) patients. The authors… CONTINUE READING