Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices

@article{Arai1996EffectOT,
  title={Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices},
  author={Amy C. Arai and Alessandro Guidotti and Erminio Costa and Gary Lynch},
  journal={NeuroReport},
  year={1996},
  volume={7},
  pages={2211–2215}
}
IDRA 21 (7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide) has been reported to modulate AMPA receptor kinetics and to improve memory in certain animal models. In the present study, its effects on synaptic transmission and long-term potentiation (LTP) were tested in hippocampal slices. IDRA 21 (500 μM) significantly increased the amplitude and halfwidth of field EPSPs. The drug did not affect mono-synaptic IPSPs but enhanced disynaptically-induced feedforward IPSPs… 

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