Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices

  title={Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices},
  author={Amy C. Arai and Alessandro Guidotti and Erminio Costa and Gary Lynch},
IDRA 21 (7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide) has been reported to modulate AMPA receptor kinetics and to improve memory in certain animal models. In the present study, its effects on synaptic transmission and long-term potentiation (LTP) were tested in hippocampal slices. IDRA 21 (500 μM) significantly increased the amplitude and halfwidth of field EPSPs. The drug did not affect mono-synaptic IPSPs but enhanced disynaptically-induced feedforward IPSPs… 

Investigation of the Functional Effects of Two Novel Ampakines in the CNS

The semi-quantitative [C]-2-deoxyglucose model was reproducible and accurate and thus could be further used to investigate the effects of the novel Ampakines, Org 26576 and Org 24448, on cerebral function.

Nootropic agents enhance the recruitment of fast GABAA inhibition in rat neocortex.

The findings indicate that AMPAR modulators strengthen inhibition in neocortical pyramidal cells, most likely by altering the kinetics of AMPARs on synaptically connected interneurons and possibly by modulating GABA(A) receptor responses in pyramsidal cells.

Positive Modulators of AMPA-Type Glutamate Receptors

Experimental work prompted by this observation indicates that chronic ampakine treatments cause sizeable improvements in animal models of Parkinson disease, excitotoxic brain damage, and age-related losses of synaptic plasticity.

Positive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Modulators Have Different Impact on Synaptic Transmission in the Thalamus and Hippocampus

The regional selectivity of benzamide drugs (ampakines) may be explained by a lower potency at thalamic AMPA receptors, perhaps due to the prevalence of the subunits GluR3 and 4.

Antidepressant-Like Effects of CX717, a Positive Allosteric Modulator of AMPA Receptors

The results show that CX717 has a rapid but not sustained antidepressant action possibly caused by rapid increases of BDNF and p11 in the forced swim test, and low-impact positive allosteric modulators of the AMPA receptors, ampakine, are examined.