Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine

@article{Young2006EffectOT,
  title={Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine},
  author={Richard Young and Tatiana S Bondareva and Anna Wesołowska and Shawquia Young and Richard A Glennon},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={85},
  pages={170-177}
}

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RationaleReports have indicated that administration of nicotine inhibits, while withdrawal of chronically administered nicotine augments effects of serotonergic 5HT2A/2C agonists.ObjectiveIt was our

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Is the dopaminergic system involved in the central effects of nicotine in mice?

TLDR
The data indicate that the dopamine receptors D1 and D2 are not involved in all the central effects of nicotine in mice, but seems to be a substrate for locomotor activation induced by nicotine under specific experimental conditions.