Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine

@article{Young2006EffectOT,
  title={Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine},
  author={Richard Young and Tatiana S Bondareva and Anna Wesołowska and Shawquia Young and Richard A Glennon},
  journal={Pharmacology Biochemistry and Behavior},
  year={2006},
  volume={85},
  pages={170-177}
}
The 5-HT(6) serotonin receptor antagonist MS-245 neither substitutes for nor antagonizes the discriminative stimulus effects of (-)nicotine. However, MS-245 was shown to enhance the potency of (-)nicotine in Sprague-Dawley rats trained to discriminate 0.6 mg/kg of (-)nicotine from saline vehicle in a typical two-lever drug discrimination paradigm such that a combination of MS-245 (5.0 mg/kg) plus the ED(50) dose of (-)nicotine caused the animals to respond as if they had received the training… Expand
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