Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine

  title={Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine},
  author={Richard Young and Tatiana S Bondareva and Anna Wesołowska and Shawquia Young and Richard A Glennon},
  journal={Pharmacology Biochemistry and Behavior},

The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats

It is indicated that concomitant inhibition of MAOA and MAOB can enhance the discriminative stimulus effect of nicotine in rats.

Chronic treatment with a selective 5-HT6 receptor antagonist alters the behavioral and neurochemical effects of ethanol in young adult rats

The effects of a potent and selective 5-HT6 receptor antagonist (compound A) on voluntary ethanol intake and behavioral/neurochemical changes induced by ethanol were studied and compound A significantly decreased voluntary ethanol consumption and attenuated the effects of ethanol on motor learning.

Serotonin receptors as potential targets for modulation of nicotine use and dependence.

Neuropharmacology of the interoceptive stimulus properties of nicotine.

Avenues for future research should include assessing the mechanisms of the subjective effects of nicotine withdrawal, factors contributing to individual differences in sensitivity to the nicotine cue, and the role of behavioral factors involved in drug cross-substitution.

Recognising nicotine: the neurobiological basis of nicotine discrimination.

Interactions of nicotine with caffeine and cannabinoids strengthen proposals that the use of one substance serves as a "gateway" in sequential shifts of the target substance for drug-seeking behaviour, with profound implications for the human use of the substances concerned.

The role of serotonin in drug use and addiction

The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer’s disease

The role of this recently discovered G protein-coupled receptor in cognition and memory, particularly in Alzheimer’s disease, is discussed and the current status of structure–activity relationship studies that have focused on the design of novel antagonists for the serotonin 6 receptor are explored.



Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus

Attenuation of nicotine’s discriminative stimulus effects in rats and its locomotor activity effects in mice by serotonergic 5-HT2A/2C receptor agonists

RationaleReports have indicated that administration of nicotine inhibits, while withdrawal of chronically administered nicotine augments effects of serotonergic 5HT2A/2C agonists.ObjectiveIt was our

Nicotine and bupropion share a similar discriminative stimulus effect.

Dopaminergic mediation of the stimulant generalization of nicotine

Is the dopaminergic system involved in the central effects of nicotine in mice?

The data indicate that the dopamine receptors D1 and D2 are not involved in all the central effects of nicotine in mice, but seems to be a substrate for locomotor activation induced by nicotine under specific experimental conditions.