Effect of tetracaine on membrane-bound acetylcholinesterase activity and anilinonaphthalene sulphonate-induced membrane fluorescence.

Abstract

Tetracaine (25-300 microM) reversibly inhibits (in vitro) AChE activity of rat brain synaptosome (4.4-100%) and erythrocyte membrane (3.9-65.2%) in a concentration dependent manner. IC50 values of tetracaine for AChE of synaptosome and erythrocyte membrane are 88 and 200 microM respectively. At sub-inhibitory concentrations (less than or equal to 10 microM… (More)

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