Effect of testosterone on insulin-like growth factor-I, androgen receptor, and myostatin gene expression in splenius and semitendinosus muscles in sheep.

@article{Mateescu2005EffectOT,
  title={Effect of testosterone on insulin-like growth factor-I, androgen receptor, and myostatin gene expression in splenius and semitendinosus muscles in sheep.},
  author={Raluca G. Mateescu and Michael L. Thonney},
  journal={Journal of animal science},
  year={2005},
  volume={83 4},
  pages={
          803-9
        }
}
Testosterone is known to act differentially on skeletal muscle from different regions. Two genes likely to mediate the testosterone effect are IGF-I, an important growth regulator acting in an autocrine and paracrine way, and androgen receptor (AR), as receptor density could account for differential muscle growth. Another muscle-specific gene that may play a role in differential muscle growth is myostatin, a member of the transforming growth factor-beta superfamily, shown to be a negative… 
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References

SHOWING 1-10 OF 23 REFERENCES
Gene expression in sexually dimorphic muscles in sheep.
TLDR
The results show that locally produced IGF-I and the regulation of AR expression may be important for sexually dimorphic muscle growth patterns.
Effects of muscle type, castration, age, and compensatory growth rate on androgen receptor mRNA expression in bovine skeletal muscle.
TLDR
The results show that AR expression is muscle-specific and may be modulated by circulating testicular hormones, and suggest that the regulation of AR expression may be linked to allometric muscle growth patterns in cattle and compensatory gain in steers.
Ontogeny of growth hormone, insulin-like growth factor-I, estradiol and cortisol in the growing lamb: effect of testosterone.
TLDR
Investigation of whether different physiological concentrations of testosterone alter muscle growth in sheep through modification of the somatotropic axis found increased muscle growth due to testosterone appeared to be caused either by a direct effect or by increased levels of IGF-I independent of circulating GH concentrations.
Quantification of insulin-like growth factor-1 (IGF-1) mRNA: modulation of growth intensity by feeding results in inter- and intra-tissue-specific differences of IGF-1 mRNA expression in steers.
  • M. Pfaffl, F. Schwarz, H. Sauerwein
  • Biology
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • 1998
TLDR
The results support that the liver is the main IGF-1 producing tissue and indicate that skeletal muscle, in particular when taking its absolute mass into account, might considerably contribute to the IGF- 1 levels in blood.
Androgen and estrogen receptors in bovine skeletal muscle: relation to steroid-induced allometric muscle growth.
TLDR
The pronounced sensitivity to estrogens and androgens in the neck, shoulder, and hind leg of calves, being free of the respective hormone, may partly explain the characteristic conformation in calves treated with estrogenic and androgenic steroids and the sexual dimorphism of muscle growth.
IGF-I and insulin receptors in bovine skeletal muscle: comparisons of different developmental ages, two different genotypes and various individual muscles.
  • A. Bŏge, H. Sauerwein, H. Meyer
  • Biology
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • 1995
TLDR
No relationship could be established between receptor concentration and fibre type composition or growth impetus in bovine skeletal muscle of two cattle breeds, and no divergence in IGF-I nor insulin receptor concentrations was observed in any of the adult animals.
Effect of testosterone on differential muscle growth and on protein and nucleic acid concentrations in muscles of growing lambs.
TLDR
This model could be used to study the gene regulation of testosterone-induced muscle growth with the possibility of invoking similar effects in more economically important muscles.
Hormonal regulation of human muscle protein metabolism.
TLDR
A greater understanding of theregulation of the regulation of human muscle protein metabolism is essential to elucidate mechanisms of muscle wasting.
Growth factor messenger RNA levels in muscle and liver of steroid-implanted and nonimplanted steers.
TLDR
Increased muscle IGF-I levels stimulate increased satellite cell proliferation, resulting in the increased muscle growth observed in Revalor-S implanted steers.
Time course of changes in growth factor mRNA levels in muscle of steroid-implanted and nonimplanted steers.
TLDR
It is hypothesized that the increased IGF-I level in muscle of implanted steers by d 7 of implantation stimulates satellite cell proliferation and maintains a high number of proliferating satellite cells at a point in the growth curve where satellite cell numbers and activity are normally dropping off.
...
1
2
3
...