Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus.

  title={Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus.},
  author={Varun Garg and R. P. G. van Heeswijk and Jee Eun Lee and K{\'a}tia Cristiane Alves and Priya P Nadkarni and Xia Luo},
  volume={54 1},
UNLABELLED The hepatitis C virus protease inhibitor telaprevir is an inhibitor of the enzyme cytochrome P450 3A, responsible for the metabolism of both cyclosporine and tacrolimus. This Phase I, open-label, nonrandomized, single-sequence study assessed the effect of telaprevir coadministration on the pharmacokinetics of a single dose of either cyclosporine or tacrolimus in two separate panels of 10 healthy volunteers each. In Part A, cyclosporine was administered alone as a single 100-mg oral… CONTINUE READING
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