Effect of tazolol on β‐adrenoceptors in isolated preparations of the guinea‐pig and rat

@article{Clark1977EffectOT,
  title={Effect of tazolol on $\beta$‐adrenoceptors in isolated preparations of the guinea‐pig and rat},
  author={S. J. Clark and R. Poyser},
  journal={Journal of Pharmacy and Pharmacology},
  year={1977},
  volume={29}
}
BOWMAN, W. C., KHAN, H. H. & SAVAGE, A. 0. (1977). J. Pharm. Pharmac., 29, 616-625. BUTTERRELD, J. L. & ELLIS, K. 0. (1973). Fedn Proc. Fedn Am. Socs exp. Biol., 32, 772. CRANEFIELD, P. F. (1975). The conduction of the cardiac impulse. Mount Kisco, New York: Futura Publishing co, ELLIS, R. H., SIMPSON, P., TATHAM, P., LEIGHTON, M. & WILLIAMS, J. (1975). Anaesthesia, 30, 318-322. ELLIS, K. O., CASTELLION, A. W., HONKOMP, L. J., WESSELS, F. L., CARPENTER, J. F. & HALLIDAY, R. P. (1973). J. oharm… Expand
8 Citations
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References

SHOWING 1-10 OF 20 REFERENCES
The roles of presynaptic function and hepatic drug metabolism in the hypothermic actions of two novel dopaminergic agonists
TLDR
This limited in vitro study has not shown the selectivity of tazolol to fll-adrenoceptors, but it has shown that the compound is a partial agonist, and act as an antagonist, at these receptors. Expand
The effect on the isolated rabbit heart of vagal stimulation and its modification by cocaine, hexamethonium and ouabain
  • L. Mcewen
  • Medicine, Chemistry
  • The Journal of physiology
  • 1956
TLDR
The experiments to be described have been concerned with the effect of vagus stimulation in the isolated heart and auricles of the rabbit and the action of cocaine, of hexamethonium and of the cardiac glycoside ouabain was studied. Expand
A comparison of the adrenergic receptor blocking properties of 1-(4'-methylphenyl)-2-isopropylamino-propanol-HCl and propranolol.
  • B. Levy
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1967
TLDR
H 35-25 appears to be capable of producing a selective blockade of vascular beta receptors in a dose range that has little blocking action on cardiac beta receptors. Expand
The adrenergic blocking activity of N-tert.-butylmethoxamine (butoxamine).
  • B. Levy
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1966
TLDR
The effects of butoxamine upon a number of adrenergic responses were determined in the anesthetized dog and the isolated rat uterus, appearing to be capable of producing a selective blockade of some, but not all, beta adrenergic receptors. Expand
Differential blockade of guinea-pig atrial rate and force responses to (--)-noradrenaline by practolol - an uptake phenomenon.
TLDR
Far from confirming the lack of receptor differentiation indicated by the pA2 determinations, this study revealed force to be more practolol sensitive and to resolve the question whether rate and force beta1-adrenoceptors differ. Expand
Selective adrenergic stimulant actions of 1-isopropylamino-3-(2-thiazoloxy)-2-propanol (ITP) in anesthetized cats.
TLDR
ITP was found to produce a long lasting increase in the sinotrial heart rate are in myocardial contractile force in anesthetized cats and its spectrum of activity places it in the category of a selective beta-1 stimulant agent. Expand
Salbutamol: a new, selective β‐adrenoceptive receptor stimulant
1 Salbutamol is a β‐adrenoceptive receptor stimulant. Its pharmacological actions are reduced or abolished by β‐receptor antagonists. 2 In anaesthetized animals, salbutamol, given intravenously, wasExpand
Differentiation of Receptor Systems activated by Sympathomimetic Amines
TLDR
Additional studies are reported which show that two distinct receptor types are at present included within this group of receptor types, and cannot be explained easily on the assumption that the β-type designates a single receptor population. Expand
A new preparation of the isolated intact trachea of the guinea‐pig
A preparation is described in which the guinea‐pig isolated intact trachea is subjected to repeated transmural electrical stimulation with alternating square wave pulses. The intraluminal pressure isExpand
Conduction of the Cardiac Impulse
TLDR
The results prove that conduction delays great enough to permit re-entry can occur in short segments of Purkinje fibers subjected to high K+. Expand
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