Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation.

@article{Xie2002EffectOT,
  title={Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation.},
  author={Qing Xie and Vladimir I. Khaoustov and Charles Y. C. Chung and Joohyun Sohn and Bhuvaneswari Krishnan and Dorothy E. Lewis and Boris Yoffe},
  journal={Hepatology},
  year={2002},
  volume={36 3},
  pages={592-601}
}
Activation of death receptors and mitochondrial damage are well-described common apoptotic pathways. Recently, a novel pathway via endoplasmic reticulum (ER) stress has been reported. We assessed the role of tauroursodeoxycholic acid (TUDCA) in inhibition of caspase-12 activation and its effect on calcium homeostasis in an ER stress-induced model of apoptosis. The human liver-derived cell line, Huh7, was treated with thapsigargin (TG) to induce ER stress. Typical morphologic changes of ER… CONTINUE READING

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