Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.

@article{Chitnis2001EffectOT,
  title={Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.},
  author={Tanuja Chitnis and Nader Najafian and Christina Benou and Alan David Salama and M. J. Grusby and Mohammed H. Sayegh and Samia J Khoury},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 5},
  pages={
          739-47
        }
}
Experimental autoimmune encephalomyelitis (EAE) is mediated by myelin-specific CD4(+) T cells secreting Th1 cytokines, while recovery from disease is associated with expression of Th2 cytokines. Investigations into the role of individual cytokines in disease induction have yielded contradictory results. Here we used animals with targeted deletion of the STAT4 or STAT6 genes to determine the role of these signaling molecules in EAE. The STAT4 pathway controls the differentiation of cells into a… CONTINUE READING

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