Effect of target structure on cross-linking by psoralen-derivatized oligonucleoside methylphosphonates.


A series of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates were examined for their abilities to cross-link to DNA and RNA oligonucleotide targets. These targets were designed to have either a random coil or a hairpin structure in solution. The methylphosphonate oligomers cross-linked with approximately the same rates to the random coil DNA… (More)


  • Presentations referencing similar topics