Effect of tapped density, compacted density, and drug concentration on light-induced fluorescence response as a process analytical tool.

@article{Shah2015EffectOT,
  title={Effect of tapped density, compacted density, and drug concentration on light-induced fluorescence response as a process analytical tool.},
  author={Ishan G. Shah and Kevin J. Ely and William C. Stagner},
  journal={Journal of pharmaceutical sciences},
  year={2015},
  volume={104 5},
  pages={1732-40}
}
The effect of tapped density, compacted density, and fluorescent drug concentration on the light-induced fluorescence (LIF) response is reported. The fluorescent response to powder mixtures containing 0.25%-10.00% w/w fluorescent active pharmaceutical ingredient (API) was evaluated over a density range of about 0.641-1.370 g/cm(3) . Blend concentrations up to 4.00% w/w API showed a linear trend in LIF response with increasing tapped and compacted density. API concentrations of 4.00% w/w or… CONTINUE READING

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