Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice.

Abstract

The metabolic effects of antiaging Klotho were previously investigated in vivo by genetic manipulation. We have here studied the metabolic effect of physiologic levels of circulating full length Klotho in db/db mice. Increasing the full-length human Klotho levels has a positive effect on blood glucose through increasing insulin secretion. 
DOI: 10.1016/j.diabres.2016.01.006

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