Effect of systemic treatment with cholesterol-lowering drugs on the skin barrier function in humans.

@article{Ramsing1995EffectOS,
  title={Effect of systemic treatment with cholesterol-lowering drugs on the skin barrier function in humans.},
  author={D W Ramsing and Erik Agner and Jacek Malinowski and J Meibom and Tove Agner},
  journal={Acta dermato-venereologica},
  year={1995},
  volume={75 3},
  pages={198-201}
}
The intercellular lipids of stratum corneum are predominantly formed by cholesterol, ceramides and free fatty acids. Cholesterol synthesis is inhibited by statins, cholesterol-lowering drugs (lovastatin, pravastatin, simvastatin). The present study was undertaken to examine the effect of these drugs on skin barrier function. Knowledge about the effect on epidermis of systemic inhibition of cholesterol synthesis may improve our understanding of the skin barrier function. Seventeen statin-treated… CONTINUE READING
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