Effect of synthetic cannabinoids on elevated intraocular pressure.
@article{Tiedeman1981EffectOS, title={Effect of synthetic cannabinoids on elevated intraocular pressure.}, author={James S. Tiedeman and Milton Bruce Shields and Pamela A. Weber and James W. Crow and David M. Cocchetto and William A. Harris and John F. Howes}, journal={Ophthalmology}, year={1981}, volume={88 3}, pages={ 270-7 } }
36 Citations
A submicron emulsion of HU-211, a synthetic cannabinoid, reduces intraocular pressure in rabbits
- MedicineGraefe's Archive for Clinical and Experimental Ophthalmology
- 2000
It is demonstrated that HU-211, incorporated into submicron emulsion, caused a 6-h-long reduction in IOP in the treated eye, with a lesser reduction in the contralateral untreated eye.
Marihuana and Intraocular Pressure
- Medicine
- 1999
Clinical and basic data indicate that marihuana or cannabinoid inhalation, and oral cannabinoids, reduce IOP in 60 to 65% of normal or glaucoma volunteers, and that the IOP reduction occurs via a primary effect on ocular fluid outflow pathways.
Cannabinoids for treatment of glaucoma
- MedicineCurrent opinion in ophthalmology
- 2016
The pharmacology of marijuana and its effect on intraocular pressure has not changed since the research in the 1970s and 1980s, and marijuana is an effective ocular hypotensive agent, however, cardiovascular and neurological effects are observed at the same dose.
MARIJUANA AND THE EYE - A REVIEW
- Medicine
- 1982
A perspective is presented on the use of marijuana and its constituents in the treatment of glaucoma, concluding that although it is undisputed that smoking of the raw material causes a fall in intraocular pressure, continued use in this mode leads to substantial pathological changes.
Cannabinoids in Glaucoma Patients: The Never-Ending Story
- BiologyJournal of clinical medicine
- 2020
PRISMA guidelines have been used to perform a literature search on Pubmed and Scopus aiming to investigate the mechanism of IOP lowering effects and the potential benefits of orally administered, inhaled, topical, and intravenous cannabinoids in the treatment of glaucoma patients.
Ocular toxicology of marijuana: an update
- Chemistry
- 1987
The cannabinoids, as represented by cannabigerol and new prodrugs, may provide a novel approach to their clinical use and the water-soluble compounds have been shown to cause morphologic effects in the eye that correlate with the changes in intraocular pressure.
The arguments for and against cannabinoids application in glaucomatous retinopathy.
- Medicine, BiologyBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2017
Marihuana and the Treatment of Glaucoma
- Medicine
- 1999
A trial on oral dronabinol (Δ9-THC), which is available as a Shedule II narcotic agent under the Controlled Substances Act, might be considered for patients with glaucoma in whom all approved methods of treatment, including surgery, have failed to stop progressive visual deterioration.
Cannabinoids as New Drug Candidates for the Treatment of Glaucoma.
- Biology, MedicinePlanta medica
- 2022
The potential of cannabinoids, primarily tetrahydrocannabinol, THCVS, and cannabinol, as drug candidates and the role of CB1/CB2 receptors with regard to the pathophysiology of glaucoma are analyzed.
References
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