Effect of synthetic cannabinoids on elevated intraocular pressure.

  title={Effect of synthetic cannabinoids on elevated intraocular pressure.},
  author={James S. Tiedeman and Milton Bruce Shields and Pamela A. Weber and James W. Crow and David M. Cocchetto and William A. Harris and John F. Howes},
  volume={88 3},

A submicron emulsion of HU-211, a synthetic cannabinoid, reduces intraocular pressure in rabbits

It is demonstrated that HU-211, incorporated into submicron emulsion, caused a 6-h-long reduction in IOP in the treated eye, with a lesser reduction in the contralateral untreated eye.

Marihuana and Intraocular Pressure

Clinical and basic data indicate that marihuana or cannabinoid inhalation, and oral cannabinoids, reduce IOP in 60 to 65% of normal or glaucoma volunteers, and that the IOP reduction occurs via a primary effect on ocular fluid outflow pathways.

Cannabinoids for treatment of glaucoma

  • G. Novack
  • Medicine
    Current opinion in ophthalmology
  • 2016
The pharmacology of marijuana and its effect on intraocular pressure has not changed since the research in the 1970s and 1980s, and marijuana is an effective ocular hypotensive agent, however, cardiovascular and neurological effects are observed at the same dose.


A perspective is presented on the use of marijuana and its constituents in the treatment of glaucoma, concluding that although it is undisputed that smoking of the raw material causes a fall in intraocular pressure, continued use in this mode leads to substantial pathological changes.

Cannabinoids in Glaucoma Patients: The Never-Ending Story

PRISMA guidelines have been used to perform a literature search on Pubmed and Scopus aiming to investigate the mechanism of IOP lowering effects and the potential benefits of orally administered, inhaled, topical, and intravenous cannabinoids in the treatment of glaucoma patients.

Ocular toxicology of marijuana: an update

The cannabinoids, as represented by cannabigerol and new prodrugs, may provide a novel approach to their clinical use and the water-soluble compounds have been shown to cause morphologic effects in the eye that correlate with the changes in intraocular pressure.

The arguments for and against cannabinoids application in glaucomatous retinopathy.

Cannabinoids and the eye.

Marihuana and the Treatment of Glaucoma

A trial on oral dronabinol (Δ9-THC), which is available as a Shedule II narcotic agent under the Controlled Substances Act, might be considered for patients with glaucoma in whom all approved methods of treatment, including surgery, have failed to stop progressive visual deterioration.

Cannabinoids as New Drug Candidates for the Treatment of Glaucoma.

The potential of cannabinoids, primarily tetrahydrocannabinol, THCVS, and cannabinol, as drug candidates and the role of CB1/CB2 receptors with regard to the pathophysiology of glaucoma are analyzed.



Acute Dose Response of Intraocular Pressure to Topical and Oral Cannabinoids

  • K. GreenK. Kim
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1977
Three nitrogen-containing can-nabinoids caused a dose-dependent fall of intraocular pressure when administered either topically or orally to rabbits and rhesus monkeys, and may prove therapeutically useful in the treatment of elevated intraocular Pressure.

Preclinical Neuropharmacology of Three Nitrogen-Containing Heterocyclic Benzopyrans Derived from the Cannabinoid Nucleus

The centuries of folklore ascribing medicinal properties to cannabis in the areas of pain relief, sedation, digestive problems, and mood elevation (Snyder, 1971; Li, 1974) have culminated in the

Clinical and psychological effects of marihuana in man.

The primitive state of knowledge of the drug, the research problems encountered in designing a replicable study, and the results of the investigations are described.


This paper is a final report on the driving and psychomotor tracking studies conducted by the Canadian Commission of Inquiry into the Non-Medical Use of Drugs (LeDain Commission). Preliminary reports

The ocular effects of cannabinoids.

  • K. Green
  • Medicine
    Current topics in eye research
  • 1979

Marihuana in Ophthalmology-past, present and future.

  • K. Green
  • Medicine
    Annals of ophthalmology
  • 1979

Marihuana and alcohol, Time production and memory functions.

In a double-blind study, time production tasks and clinical tests of memory function were performed by 15 normal subjects given placebo and "social" doses of alcohol and marihuana, calibrated to (-)-δ 1 -tetrahydrocannabinol, and it was found that marhuana induced a significant under production of time intervals suggesting an acceleration of the internal clock.