Effect of synthesized inhibitors on babesipain-1, a new cysteine protease from the bovine piroplasm Babesia bigemina.

@article{Martins2010EffectOS,
  title={Effect of synthesized inhibitors on babesipain-1, a new cysteine protease from the bovine piroplasm Babesia bigemina.},
  author={Tiago F. M. C. Martins and L{\'i}dia Maria Gonçalves and Rita Capela and Rui Moreira and Virg{\'i}lio Est{\'o}lio do Ros{\'a}rio and Ana Domingos},
  journal={Transboundary and emerging diseases},
  year={2010},
  volume={57 1-2},
  pages={68-9}
}
Papain-like cysteine proteases (CP) have been shown to have essential roles in parasitic protozoa and are under study as promising drug targets. One gene was identified by sequence similarity search to be homologous to the CP family in the ongoing Babesia bigemina genome sequencing project database. The newly identified CP gene, called babesipain-1, was cloned and expressed as a fusion protein, and the effect of different inhibitors on proteolytic activity was tested. A series of new… CONTINUE READING

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