Effect of synaptically active substances on the hyperthermic effect of prostaglandin E2 in rats

@article{Gurin2004EffectOS,
  title={Effect of synaptically active substances on the hyperthermic effect of prostaglandin E2 in rats},
  author={V. N. Gurin and F. I. Vismont and V. V. Tsaryuk},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={91},
  pages={310-312}
}
It was established in experiments on unanesthetized rats given intraventricular injections of drugs that hyperthermic effect of prostaglandin E2 (PGE2) was markedly weakened by administering clofelin while isoproterenol had no appreciable effect on PGE2 effects were not prevented by noradrenaline, 5-hydroxytryptamine, phenoxybenzamine, propranolol, deseril, nicotine, metamyzyl and IEM-506. Preliminary administration of oxotremorine and hemicholinium-3 averted PGE2 effect. The disorders of the… 
View on Springer
ncbi.nlm.nih.gov

References

SHOWING 1-8 OF 8 REFERENCES
Pyrogen and prostaglandin fever in the rabbit—II: Effects of noradrenaline depletion and adrenergic receptor blockade
Fever produced by prostaglandin E1
Prostaglandin E1 (PGE1) produces a rise in rectal temperature when injected into the cerebral ventricles of unanaesthetized cats, rabbits and rats. An effect is obtained with as little as 20, and…
Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits
1. Prostaglandins were injected into the third ventricle of unanaesthetized cats and rabbits whilst rectal temperature was recorded.
Prostaglandin E1 fever induced in rabbits
  • J. Stitt
  • Biology, Medicine
    The Journal of physiology
  • 1973
TLDR
Micro‐injections of prostaglandin E1 (PGE1) into the anterior hypothalamus of the rabbit produced fever which was nearly immediate in onset, similar to fever sensitive to leucocytic pyrogen in mice.
Hemicholinium-3: Noncholinergic Effects on Squid Axons
TLDR
Voltage-clamp experiments show that hemicholinium-3 depresses both the early transient and late steady-state components of membrane ionic conductances, with a greater effect on the peak transient component.
Persistence of febrile response to pyrogens after PO/AH lesions in squirrel monkeys.
TLDR
It appears that in the brains of primates there is either multiple central representation of fever control or an inherent capacity to develop sensitivity to pyrogens and to produce coordinated febrile responses.
Recent studies of hypothalamic function: K. Lederis and K.E. Cooper (Editors). Proceedings of the International Symposium, Calgary, 1973. (S. Karger, Basel, 1974, 434 p., 137 Fig., 17 Tables, DM 128.00, U.S. $49.25).
Monoamines, pyrogens and cations: their actions on central control of bodytemperature.
  • R. Hellon
  • Chemistry, Medicine
    Pharmacological reviews
  • 1974