Effect of symptoms on executive function in bipolar illness

  title={Effect of symptoms on executive function in bipolar illness},
  author={T. Dixon and Eugenia Kravariti and Chris D. Frith and Robin M. Murray and Philip McGuire},
  journal={Schizophrenia Research},
Background. The relationship between cognitive function and symptomatology in bipolar disorder is unclear. This study assessed executive function during the manic, depressed and remitted stages of bipolar I disorder. Method. Tasks assessing phonological and semantic verbal fluency, the Hayling Sentence Completion Test, the Stroop Neuropsychological Screening Test and the Cognitive Estimates Test were administered to manic (n=15), depressed (n=15), and remitted (n=15) bipolar I patients, and to… 

Association of executive dysfunctions and symptoms in a sample of bipolar affective disorder patients

Manic symptoms had a significant effect on cognitive functions and showed worsening in the executive function associated with manic than with depressive symptoms.

Cognitive functioning in a depressive period of bipolar disorder

In patients with bipolar depression cognitive assessment should be taken into account in the diagnosis and the disturbances in executive functions and working memory should be treated with neuropsychological rehabilitation and / or pharmacotherapy.

Cognitive functioning in depression period of bipolar disorder

In patients with bipolar depression cognitive assessment should be taken into account in the diagnosis and the disturbances in executive functions and working memory should be treated with neuropsychological rehabilitation and / or pharmacotherapy.

Neurocognitive functioning in bipolar depression: a component structure analysis

Overall, neurocognitive test performance is significantly reduced in bipolar disorder patients when depressed, along with the use of different methods of analysing cognitive performance, indicating important directions for future research.

Insight, symptoms and neurocognition in bipolar I patients.

Cognitive Functions in Bipolar Manic, Depressed and Remission Episodes

It was found that attention, memory and learning functions were worse in the manic and depressive patients than healthy controls or patients in remission and that the number of depressive episodes had a negative effect on attention functions.

Outcome of cognitive performances in bipolar euthymic patients after a depressive episode: a longitudinal naturalistic study

A certain degree of impairment remained even after the remission of the affective episode in relationship with the executive functions in bipolar patients following a depressive episode, after a 6-month period in the absence of mood symptoms.

[Cognitive functioning in depression and the course of bipolar affective disorder].

Neuropsychological impairment in bipolar disorder seems to be stable trait, independent from intensity of depressive symptoms and they progress with course of illness measured by number of hospitalizations.

Functional outcome in bipolar disorder: the role of clinical and cognitive factors.

Low-functioning patients were cognitively more impaired than highly functioning patients on verbal recall and executive functions and the variable that best predicted psychosocial functioning in bipolar patients was verbal memory.



Neuropsychological function in euthymic patients with bipolar disorder

These findings provide good evidence for the existence of neuropsychological impairment in patients with euthymic bipolar disorder, although the possible effect of medication should not be overlooked.

Cognitive impairment in remission in bipolar affective disorder

It is demonstrated that patients in remission show a relatively specific impairment in memory with recovery of accuracy measures on executive function task, suggesting that in neuroanatomical terms, more posterior cortical function (temporal lobe) has not improved but there is at least some recovery of frontal lobe function in remission.

Cognitive function in euthymic Bipolar I Disorder

Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological test battery.

It is suggested that patients with schizophrenia perform systematically worse on cognitive measures than patients with affective disorders, which is consistent with their generally poorer outcome.

Sustained attention deficit in bipolar disorder.

Sustained attention deficit may represent a neuropsychological vulnerability marker for bipolar disorder, providing a focus for further understanding of the phenotype and analysis of the neuronal networks involved.

Persistent attentional dysfunction in remitted bipolar disorder.

The findings suggest that impairments in fine motor skills and reaction time may be present in clinically stable patients with BPD, even after accounting for psychiatric symptoms and medication effects.

Neuropsychological function in subjects with psychotic and affective disorders. Relationship to diagnostic category and duration of illness.

  • H. VerdouxF. Liraud
  • Psychology, Medicine
    European psychiatry : the journal of the Association of European Psychiatrists
  • 2000

Cognitive Dysfunctions in Bipolar Disorder: Evidence of Neuropsychological Disturbances

Methodological limitations warrant further research in order to clear up the relationship between neuropsychological functioning and clinical, demographic and treatment variables in bipolar disorder.

Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery

Case-control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania.

Impaired verbal learning and memory may be a trait variable in bipolar disease and implications for adherence to medication and relapse and for the role of early treatment interventions are explored.