Effect of sustained virological response to treatment on the incidence of abnormal glucose values in chronic hepatitis C.

Abstract

BACKGROUND/AIMS To investigate the effect of sustained virological response (SVR) on impaired fasting glucose (IFG) and/or type 2 diabetes (T2DM); to assess the influence of glucose abnormalities on the SVR rate. METHODS 1059 patients with chronic HCV; normal glucose (< 100 mg/dl) in 734, IFG (between 100 and 125 mg/dl) in 218, and T2DM (126 mg/dl) in 107 cases, were treated with interferon plus ribavirin over 24 or 48 weeks, depending on viral genotype. RESULTS The SVR rate was lower in patients with IFG and/or T2DM than in patients with normal glucose concentrations [143/325 (44%) vs. 432/734 (58.8%); P=0.002]. In the follow-up, abnormal glucose concentrations were observed in 74 of 304 (24.3%) non-responders and in 49 of 430 (11.4%) sustained responders (log-rank: 13.8; P=0.00002). Reverse stepwise logistic regression analysis identified the independent variables predictive of IFG or T2DM development as: sustained response (OR: 0.44; 95%CI=0.20-0.97; P=0.004) and fibrosis stage (OR: 1.46; 95%CI=1.06-2.01;P=0.02). Family history of DM, steatosis, gender, HCV viral load, genotype, triglycerides, cholesterol and BMI did not enter the multivariate analysis equation. CONCLUSIONS SVR reduces the risk of IFG and/or T2DM development in patients with chronic hepatitis C while altered glucose metabolism impairs sustained response to viral treatment.

DOI: 10.1016/j.jhep.2007.11.022

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@article{RomeroGmez2008EffectOS, title={Effect of sustained virological response to treatment on the incidence of abnormal glucose values in chronic hepatitis C.}, author={Manuel Romero-G{\'o}mez and Conrado Manuel Fern{\'a}ndez-Rodr{\'i}guez and Ra{\'u}l Jes{\'u}s Andrade and Mois{\'e}s Diago and Sonia Marcos Alonso and Ramon Planas and Ricard Sol{\'a} and Jos{\'e} Antonio Pons and Javier Salmer{\'o}n and Rafael B{\'a}rcena and Ram{\'o}n M P{\'e}rez and Isabel Carmona and Santiago Dur{\'a}n}, journal={Journal of hepatology}, year={2008}, volume={48 5}, pages={721-7} }