Effect of surgical repair on testosterone production in infertile men with varicocele: A meta‐analysis

@article{Li2012EffectOS,
  title={Effect of surgical repair on testosterone production in infertile men with varicocele: A meta‐analysis},
  author={Fuping Li and Huan-xun Yue and Kohei Yamaguchi and Keisuke Okada and Kei Matsushita and Makoto Ando and Koji Chiba and Masato Fujisawa},
  journal={International Journal of Urology},
  year={2012},
  volume={19}
}
Objectives:  To determine the effect of surgical varicocele repair in improving testicular Leydig cell function as shown by increased testosterone production. 
Extended indications for varicocelectomy
TLDR
The literature regarding varix ligation as a treatment for non-obstructive azoospermia, elevated DNA fragmentation, and hypogonadism is examined. Expand
Testosterone and Varicocele.
TLDR
In this review, the evidence linking varicoceles to impaired steroidogenesis and which cohorts of men may benefit most from varicocele repair are discussed. Expand
Should a Varicocele Be Repaired in Non-infertile Patients with Hypogonadism?
TLDR
There is a growing evidence that varicocele may also jeopardize Leydig cell function with consequential impairment of testosterone biosynthesis and hypogonadism, which could be reversed with varicocelectomy. Expand
Effect of microsurgical varicocele repair on sexual functions and testosterone in hypogonadal infertile men with varicocele
  • B. Saylam, S. Çayan, E. Akbay
  • Medicine
  • The aging male : the official journal of the International Society for the Study of the Aging Male
  • 2020
TLDR
Data suggest that serum total testosterone level, IIEF-EF score and sexual libido significantly increase after varicocele surgery, and varicoCele repair could be offered to hypogonadal men with clinicallyvaricocele. Expand
The role of microsurgical varicocelectomy in treating male infertility
TLDR
The role of varicocelectomy is discussed in the treatment of the modern infertile male and a practical, safe, and reproducible technique for the microsurgical approach is presented. Expand
Varicocele and Hypogonadism
TLDR
It is demonstrated that microsurgical varicocelectomy improves testosterone levels in men with varicocele and low testosterone preoperatively and on testosterone level during and after surgery. Expand
Surgical management of adolescent varicocele: Systematic review of the world literature
TLDR
This work sought to review the published literature in a systematic manner to gain an overview and streamline the presentations and main treatment modalities of symptomatic varicocele. Expand
Surgical and Radiological Correction of Varicocele in Infertile Male: Sexuality and Quality of Life
TLDR
Although clinical studies have examined more topics in the surgical and radiological fields, the impact of these treatments on the body scheme and on the virility and integrity of the patient is not so numerous. Expand
Effects of Varicocele on Serum Testosterone Levels and Changes of Testosterone Levels after Varicocelectomy among Infertile Men: A Prospective Controlled Study
TLDR
Varicocelectomy was demonstrated to significantly improve both sperm quality as well as serum testosterone in infertile men, especially in cases with hypogonadism. Expand
Effects of varicocelectomy on serum testosterone
TLDR
The findings suggest that microsurgical varicocele repair can improve serum testosterone in men with low levels preoperatively in appropriately counseled men. Expand
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References

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The effect of microsurgical varicocelectomy on serum follicle stimulating hormone, testosterone and free testosterone levels in infertile men with varicocele
To analyse the effects of varicocelectomy on serum follicle‐stimulating hormone (FSH), testosterone and free testosterone levels, and to investigate the interrelationships between seminal andExpand
The effect of varicocelectomy on serum testosterone levels in infertile men with varicoceles.
TLDR
Varicocelectomy can increase serum testosterone for infertile men with varicoceles and may improve hormonal and spermatogenic function. Expand
Varicocele repair for treatment of androgen deficiency
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Although the impact of varicocele on testosterone production is not well understood and the utility ofvaricocelectomy to prevent or reduce deterioration in Leydig cell function remains unproven, recent data suggest an adverse effect of varICOcele and possible benefit of repair. Expand
Effects of varicocele on male fertility.
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There appears to be a significant difference between adults and adolescents with respect to a progressive deterioration of semen parameters and it is clear that subclinical varicoceles do not play a major role in male infertility. Expand
Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis.
TLDR
Surgical varicocelectomy in infertile men with palpable lesions and at least one abnormal semen parameter improves the odds of spontaneous pregnancy in their female partners, and suggests that varicocephalectomy in selected patients does indeed have beneficial effects on fertility status. Expand
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Varicocele is clearly associated with impairment of testicular function and infertility and was as frequent in couples in whom the men did or did not have varicocele. Expand
Incidence of varicoceles in men with primary and secondary infertility.
TLDR
Findings do not support the conclusion that varicoceles have a progressive adverse effect on fertility over time and suggest that further study is needed to determine whether varicocele repair is indicated in patients with normal semen parameters. Expand
Predictors of improved seminal parameters and fertility after varicocele repair in young adults
TLDR
It is concluded that in the general male population, varicocele repair is not associated with an improved semen profile in all cases and a significant correlation between nitric oxide concentrations and semen profile was observed. Expand
Older age is associated with similar improvements in semen parameters and testosterone after subinguinal microsurgical varicocelectomy.
TLDR
Microsurgical varicocelectomy resulted in significant increases in sperm concentration, total sperm count and testosterone in all age groups studied, including men in the fifth and sixth decades of life. Expand
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