Effect of surfactant incorporation techniques on sulphamethoxazole suppository formulations.

Abstract

In vitro release, stability as well as bioavailability of sulphamethoxazole (SMZ) suppositories were investigated using solid dispersion techniques for surfactant incorporation. Tween 20, Tween 80 and Myrj 53 were the surfactants utilized in this investigation. Suppositories were prepared by fusion method using Witepsol H15 as a base. It was found that SMZ… (More)

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