Effect of surface roughness on proliferation and alkaline phosphatase expression of rat calvarial cells cultured on polystyrene.

@article{Hatano1999EffectOS,
  title={Effect of surface roughness on proliferation and alkaline phosphatase expression of rat calvarial cells cultured on polystyrene.},
  author={Kazuhiko Hatano and Hidetake Inoue and Tohru Kojo and Taku Matsunaga and Toshiyuki Tsujisawa and Chuzo Uchiyama and Yasuo Uchida},
  journal={Bone},
  year={1999},
  volume={25 4},
  pages={439-45}
}
Rough-surfaced substrates made by a variety of methods have been shown to influence osteoblast proliferation and differentiation. The purpose of this study is to confirm the role of surface roughness in promoting osteoblastic differentiation using tissue culture polystyrene as substrate, by excluding factors other than roughness. Immature osteogenic cells derived from fetal rat calvariae were cultured on the plastic cover strips having varied degrees of roughness created by treatment with four… CONTINUE READING

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