Effect of surface-potential modulators on the opening of lipid pores in liposomal and mitochondrial inner membranes induced by palmitate and calcium ions.

@article{Belosludtsev2015EffectOS,
  title={Effect of surface-potential modulators on the opening of lipid pores in liposomal and mitochondrial inner membranes induced by palmitate and calcium ions.},
  author={Konstantin N. Belosludtsev and Natalia V. Belosludtseva and Alexey V. Agafonov and Nikita Penkov and Victor N. Samartsev and John J. Lemasters and Galina D. Mironova},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1848 10 Pt A},
  pages={2200-5}
}
The effect of surface-potential modulators on palmitate/Ca2+-induced formation of lipid pores was studied in liposomal and inner mitochondrial membranes. Pore formation was monitored by sulforhodamine B release from liposomes and swelling of mitochondria. ζ-potential in liposomes was determined from electrophoretic mobility. Replacement of sucrose as the osmotic agent with KCl decreased negative ζ-potential in liposomes and increased resistance of both mitochondria and liposomes to the pore… CONTINUE READING

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